Author

Year

Region

Study category

Reagents

Samples

Method

Pre-chemo

Post-chemo

Ref.

Mutation

Total

Mutation

Total

Munfus-McCray D

2013

US

Retrospective

Platinum-based third-generation doublets

Tissue

PCR

31

17

37

26

6

9

37

26

[9]

Hua Bai

2012

China

Retrospective

Cisplatin and carboplatin + gemcitabine, vinorelbine and taxanes

Blood

Tissue

DHPLC ARMS

91

22

264

63

61

12

264

63

[8]

Rubing HAN

2011

China

Retrospective

Cisplatin/arboplatin + gemcitabine/pemetrexed/VP-16/taxanes

Serum

Nested PCR

13

33

18

33

[10]

Hong-Gang Ke

2013

China

Retrospective

Pemetrexed + cisplatin

Tissue

PCR

61

107

70

107

[11]

Yan-E Ma

2013

China

Retrospective

Cisplatin/carboplatin + gemcitabine/vinorelbine/pemetrexed

Plasma

DHPLC

18

60

15

60

[12]

Shuhang Wang

2012

China

Retrospective

Cisplatin/carboplatin + gemcitabine/taxanes

Tissue

ARMS

22

66

12

66

[13]