Amino Acid Type

Amino Acid

Amino acid usage in Reference HBV virus [NC_00397] HBsAg gene (B)

Frequency of substitution at HBsAg gene

(Z)

(Z/B)

Hydrophobic: Aliphatic

Glycine [G]

15

10

0.67

Alanine [A]

5

55

11.00

Valine [V]

10

26

2.60

Leucine [L]

35

16

0.46

Isoleucine [I]

14

24

1.71

Proline [P]

21

18

0.86

Methionine [M]

7

2

0.29

Hydrophobic: Aromatic

Phenylalanine [F]

16

16

1.00

Tyrosine [Y]

6

5

0.83

Tryptophan [W]

13

1

0.08

Hydrophilic: Polar Uncharged

Serine [S]

25

88

3.52

Threonine [T]

19

31

1.63

Cysteine [C]

14

9

0.64

Asparagine [N]

5

17

3.40

Glutamine [Q]

7

3

0.43

Hydrophilic: Acidic

Aspartic Acid [D]

3

0

0.00

Glutamic Acid [E]

2

14

7.00

Hydrophilic: Basic

Arginine [R]

6

7

1.17

Histidine [H]

1

0

0.00

Lysine [K]

2

14

7.00