Types | Description |
ATP competitive inhibitors | · Binds to the ATP binding site of the kinase in its active conformation |
Inhibitors | · Binds to non-active conformation of ATP bindingsite |
Allosteric inhibitors | · Binds to the outside of ATP binding site · Modifies tridimensional structure of the receptor · Disrupt interaction between ATP and its kinase bindingsite |
Covalent inhibitors | · Irreversible binding of ATP binding site of kinase |