Organism | Gene(s) | Editing | Reference |
Mouse | ASXL1 | Non sense point mutation | [87] |
Mice | Human ICC/HCC | Multiplex mutagenesis | [88] |
Human | CFTR | Homozygous deletion of F508 | [89] |
Mouse | Crygc | Correction of genetic disease | [90] |
Mice | Dystrophin gene (Dmd) | Destrophin related duchenne muscular dystrohy | [91] |
Human | Cas9 nuclease and nickase | Fanconi anemia gene correction | [92] |
Mouse | AAV9 | Postnatal genome editing | [93] |
Mouse | Fah | In vivo therapies | [94] |
Mouse | PCSK9 | Mouse hepatocyte editing | [95] |
Mammalian brain | CHD8 | Autism spectrum disorder | [96] [97] |
Wild mice | PTEN & TP53 | Tumor suppressor genes | [98] [99] [100] |
Human | HIV-I | virus | [101] - [107] |
Human | Burkitt’s Lymphoma cells | Latent Herpesviridae | [108] |
Human | HPV16-E7 | Papillomavirus | [109] |
Humans | HBV cccDNA | Hepatitis-B | [110] |
Human | CXCR4 & CCR5 | AIDS | [107] [108] [111] |
Pig | PERVs | Viral disruption | [112] |
Human | Pig Alb locus | Human Albumin production | [112] |
Corn | LIG1, Ms26 and Ms45, ALS1 and 2 | Targeted mutagenesis, Precise gene editing, Site specific gene insertion | [113] |
Soybean | DD20 and DD43 | Genome editing | [111] |
Nicotiana benthamiana | ---------- | Tomato Yellow Leaf Curl Virus | [114] |
Mushrooms | ---------- | CRISPR Edited Mushrooms | [115] |