Organism

Gene(s)

Editing

Reference

Human

hESC & iPSC

Targeted genome engineering

[73]

Rat

IgM

Gene knock out

[74]

Zebrafish

pthA

Gene targeting

[75]

Zebrafish

hey2

Gene disruption

[76]

Mouse

Zic2

Site specific mutation

[77]

Tobacco

ALS (SurA & SurB)

Genome engineering

[78]

Human

XPC locus

Targeted gene therapy

[79]

Soybean

FAD2-1A & FAD2-1B

Targeted mutagenesis

[80]

Rat

GR^dim

Gene knock-in

[81]

Phaeodactylum tricornutum

UDP glucose phosphorylase gene

Targeted mutagenesis

[82]

Human

(HPFH)-175T > C

Point mutation

[83]

Cattle

SP110

Gene knock-in

[84]

Human

TRAC/dCK

TALEN mediated gene processing

[85]

Human

TCR & CD52

Multiplex genome editing

[86]