Baseline

4 weeks

8 weeks

Pigmentation

Placebo

9.5 ± 2.9

14.0 ± 4.0

(1.0 ± 5.0)

11.8 ± 4.7

(−1.3 ± 3.5)

Delphinol®

11.0 ± 5.9

15.5 ± 6.0

(−0.3 ± 5.3)

14.5 ± 9.8

(−1.3 ± 4.6)

Wrinkle number

Placebo

1.1 ± 0.8

1.1 ± 0.8

(0.0 ± 1.4)

1.6 ± 1.2

(0.5 ± 1.1)

Delphinol®

1.1 ± 0.8

1.0 ± 0.5

(−0.1 ± 0.6)

1.3 ± 0.9

(0.1 ± 0.6)

Wrinkle length

Placebo

36.3 ± 17.8

32.5 ± 26.8

(−3.8 ± 19.0)

23.5 ± 20.8

(−12.8 ± 12.3)

Delphinol®

27.6 ± 18.1

39.4 ± 31.1

(11.8 ± 21.1)

41.5 ± 23.5

(13.9 ± 24.5)

Texture

Placebo

45.8 ± 13.3

51.6 ± 12.6

(5.9 ± 9.9)

58.4 ± 5.8

(12.6 ± 15.2)

Delphinol®

53.9 ± 15.8

46.8 ± 10.7

(−7.1 ± 12.9)

54.4 ± 7.5

(0.5 ± 13.5)

Oil content

Placebo

50.4 ± 7.8

43.1 ± 12.7

(−7.3 ± 10.1)

47.0 ± 8.6

(−3.4 ± 9.3)

Delphinol®

50.5 ± 8.6

46.9 ± 11.0

(−3.8 ± 9.6)

45.9 ± 9.7

(−4.8 ± 8.9)

Water content

Placebo

86.4 ± 16.7

80.4 ± 17.3

(−6.0 ± 5.6)

85.1 ± 13.3

(−1.3 ± 4.3)

Delphinol®

91.3 ± 8.5

87.1 ± 10.4

(−4.1 ± 8.4)

90.3 ± 10.0

(−1.0 ± 6.4)

TEWL

Placebo

9.9 ± 3.6

13.8 ± 5.5

(3.9 ± 4.2)

11.6 ± 1.7

(1.7 ± 2.4)

Delphinol®

11.4 ± 5.7

15.4 ± 6.2

(4.0 ± 3.8)

13.4 ± 3.8

(2.0 ± 3.4)

Dermal thickness

Placebo

1313.4 ± 350.3

1152.0 ± 253.1

(−161.4 ± 195.7)

1229.6 ± 315.7

(−83.8 ± 89.6)

Delphinol®

1382.6 ± 384.3

1219.8 ± 392.3

(−162.9 ± 612.6)

1152.0 ± 348.6

(−230.6 ± 328.4)

Elasticity

Placebo

88.3 ± 6.2

89.4 ± 4.5

(1.1 ± 7.7)

87.1 ± 5.6

(−1.1 ± 10.2)

Delphinol®

89.4 ± 5.2

91.1 ± 4.2

(1.8 ± 6.1)

90.6 ± 3.8

(1.3 ± 5.9)