Methodologies

Ligants compounds

Structures

Acylation,

Amidation,

Imidation,

(Prosthetic group with an activated ester and a primary amine)

(1) [¹⁸F]fluorobenzoate ([¹⁸F]SFB),

(2) 4-nitrophenyl 2-[18F]fluoroproprionate ([¹⁸F]NPFP),

(3) N-succinimidyl 8-[4’-([¹⁸F]fluorobenzyl)amino]suberate ([¹⁸F]SFBS),

(4) 3-[¹⁸F]fluoro-5-nitrobenzimidate ([¹⁸F]FNB

(1)

(2)

(3)

(4)

Alkylation

(Uses free sulfhydryl groups)

(5) 4-[¹⁸F]fluorophenacyl bromide ([¹⁸F]FPB)

(5)

Thiol groups

(Based on thiol-maleimide coupling chemistry)

(6) 1-[3-(2-[¹⁸F]fluoropyridin-3-yloxy) propyl]pyrrole-2,5-dione ([¹⁸F]FPyMe),

(7) N-2-(4-[¹⁸F]fluorobenzamide)ethylmaleimide ([18F]FBEM

(6)

(7)

Photochemical conjugation

(8) 4-azidophenacyl-[¹⁸F]fluoride ([¹⁸F]APF)

(8)

Chemoselective reactions

(9) 4-[¹⁸F]fluorobenzaldehyde ([¹⁸F]FBA),

(10) (p-(di-t-butyl[¹⁸F]fluorosilyl)benzaldehyde) ([¹⁸F]SiFA-A),

(11) [¹⁸F]fluoroethylazide,

(12) [¹⁸F]fluoroalkynes

(13) [¹⁸F]glycosyl azide

(9)

(10)

(11)

(12)

(13)

Click chemistry

(14) [¹⁸F]fluoroalkynes

(15) [¹⁸F]fluoroazides

(14)

(15)

Heteroatoms

(B, Al and Si, and macrocyclic ligands)

(16) cyclo-RGD-boronic ester

(17) cyclo-RGD- ${\text{BF}}_4^{-}$

(18) silicon-based fluoride acceptor (SiFA)

(19) Aluminium-[¹⁸F]fluoride ([¹⁸F]AlF)

(16), (17)

(18)

(19)