Target Compound.

R₁

R₂

R₃

MIC (μg/mL)

Cytotoxicity

IC₅₀ (μg/mL)

H₃₇Rv

MDR-TB

XDR-TB

6

-

NH₂

CH₃

6.25

6.25

25

ND

8

-

SH

CH₃

6.25

25

>100

ND

10

-

NH₂

NH₂

6.25

12.5

50

ND

7d

CH₂Cl

-

CH₃

6.25

3.12

12.5

>62.5

7e

C₆H₅

-

CH₃

6.25

12.5

50

ND

7i

3-OMeC₆H₄

-

CH₃

1.6

3.12

12.5

>62.5

9f

-

4-OHC₆H₄

CH₃

0.8

3.12

12.5

32.5

Isoniazid

-

-

0.5

6.25

50

ND