Study type

Target population

Main purpose of the study

Method of radon dosimetry

Major finding/conclusions

Cohort studies

Miners/occupational exposure

Determine the risk of lung cancer morality in exposed miners

Radiation exposure was estimated using job-exposure matrix (JEM) which provides exposure values for potential alpha energy from radon and its progeny in working level months (WLM)

High levels of radon exposure were associated with increased cancer risk.

Case control studies

The public/residential exposure

Determine the risk of lung cancer in residential setting

Year-long residential radon levels were measured by a-track detectors and were used to estimate exposure in the 25 years prior to the index date.

Most studies reported small insignificant association between residential radon exposure and lung cancer, some studies found negative association.

Pooled analysis of the cohort studies on miners

Obtain summary estimates of the risk of lung cancer in radon-exposed miners using large sample size.

A summary of the WLM exposure was obtained for the total subjects using reported exposure levels in the individual studies.

A summary of the WLM exposure was obtained for the total subjects using reported exposure levels in the individual studies.

A consistent linear relationship for cumulative radon progeny and lung cancer was observed in the range of miner exposures

Combined analysis of case-control studies

The general public/residential exposure in Europe and North America

Obtain accurate estimates of lung cancer risk from residential radon exposure by reducing incertainity in radon dosimetry

Available radon measurements form individual studies were used to estimate radon exposure for the total individuals in all homes occupied over the past 5 - 30 years.

A significant increase in risk of lung cancer was associated with increased radon exposures with seemingly linear dose-response relationship.