Optimum dosing interval

Minimum acceptable dosing interval

Estimated duration of protection

Dose one

At first contact with health worker or as early as possible in pregnancy

At first contact with health worker or as early as possible in pregnancy

None

Dose two

6 - 8 weeks after dose one*

At least 4 weeks after dose one

1 - 3 years

Dose three

6 - 12 months after dose two*

At least 6 months after dose two or during subsequent pregnancy

At least 5 years

Dose four

5 years after dose three*

At least one year after does three or during subsequent pregnancy

At least 10 years

Dose five

10 years after dose four*

At least one year after does four or during subsequent pregnancy

All childbearing age years; possibly longer