Optimum dosing interval | Minimum acceptable dosing interval | Estimated duration of protection | |
Dose one | At first contact with health worker or as early as possible in pregnancy | At first contact with health worker or as early as possible in pregnancy | None |
Dose two | 6 - 8 weeks after dose one* | At least 4 weeks after dose one | 1 - 3 years |
Dose three | 6 - 12 months after dose two* | At least 6 months after dose two or during subsequent pregnancy | At least 5 years |
Dose four | 5 years after dose three* | At least one year after does three or during subsequent pregnancy | At least 10 years |
Dose five | 10 years after dose four* | At least one year after does four or during subsequent pregnancy | All childbearing age years; possibly longer |