Drug

Dose

Days of administration

Induction (Protocol I)

Phase A (SR/IR)

Prednisone (PO)

Vincristine (IV)

Daunorubicin (PI, 1 hour)

L-Asparaginase (PI, 1 hour)

Methotrexate (IT)

60 mg/m²/per day

1, 5 mg/m²/per dose

30 mg/m²/per dose

5000 IU/m²/per dose

12 mg per dose

1 - 28^a

8, 15, 22, 29

8, 15, 22^b, 29^b

12, 15, 18, 21, 24, 27, 30, 33

1, 12

Induction (Protocol I)

Phase B (SR/IR)

Cyclophosphamide (PI, 1 hour)

Cytarabine (ARA-C)* (PI, 1 hour)

6-Mercaptopurine (PO)

Methotrexate (IT)

1000 mg/m²/per dose

75 mg/m²/per dose

60 mg/m²/per dose

12 mg per dose

36, 64

(38 - 41), (45 - 48), (52 - 55), (59 - 62)

33 - 63

45, 49

Consolidation (Protocol M)

(pre B ALL, SR)

6-Mercaptopurine (PO)

Methotrexate (PI, 24 hours)

Methotrexate (IT)

25 mg/m²/per day

2 g/m²/per dose

12 mg per dose

1 - 56

8, 22, 36, 50

8, 22, 36, 50

Consolidation (Protocol M)

(pre B ALL IR and T ALL, SR/IR)

6-Mercaptopurine (PO)

Methotrexate (IV, 24 hours)

Methotrexate (IT)

25 mg/m²/per day

5 g/m²/per dose

12 mg per dose

1 - 56

8, 22, 36, 50

8, 22, 36, 50

Reinduction (Protocol II)

Phase 1 (SR/IR)

Dexamethasone (PO)

10 mg/m²/per day

1 - 21^a

Vincristine (IV)

1.5 mg/m²

8, 15, 22, 29

Adriamycin (IV, 1 hour)

30 mg/m²/per dose

8, 15, 22, 29

L-asparaginase (IV, 1 hour)

5000 IU/m² per dose

8, 15, 22, 29

Reinduction (Protocol II)

Phase 2 (SR/IR)

Cyclophosphamide (PI, 1 hour)

Cytarabine (PI, 1 hour)

6-Thioguanine (PO)

Methotrexate (IT)

1000 mg/m²/per dose

75 mg/m²/per dose

60 mg/m²/per day

12 mg per dose

36

38 - 41, 45 - 48

36 - 49

38, 45