Gene

Variant

Allele*

RAF

Datasets

Cases/

Controls

Risk estimates

Heterogeneity

Venice

criteria grade

FPRP

Cumulative evidence of association

OR (95%CI)

P

І2

P

CARD10

rs6000782

C/A

0.05

2

1100/17539

1.590 (1.327, 1.905)

4.88 × 10⁻⁷

12.00%

0.286

AAA

<0.001

Strong

TNF-α

rs1800629

A/G

0.14

3

183/750

1.889 (1.375, 2.595)

8.53 × 10⁻⁵

16.20%

0.303

BAC

0.003

Moderate

SH2B3

rs3184504

C/T

0.53

2

1100/17539

1.305 (1.122, 1.516)

0.001

46.30%

0.172

AAA

0.065

Strong

PTPN22

rs2488457

A, C/G

0.76

3

393/784

0.748 (0.617, 0.906)

0.003

0.00%

0.672

BAA

0.296

Weak

STAT4

rs7574865

T/G

0.23

3

2032/11058

1.489 (1.124, 1.972)

0.005

81.20%

0.005

AAA

0.167

Strong

CTLA-4

rs231775

C/T

0.6

7

1106/1645

1.177 (1.041, 1.331)

0.009

3.00%

0.403

AAC

0.223

Weak

CTLA-4

exon 1

-

-

3

286/236

1.312 (1.007, 1.710)

0.044

0.00%

0.612

BAA

0.769

Weak