| Authors | Nature of study | Year | Sample size | Judgement criteria | Superiority | Dose | Duration |
| Rosa Mc Gready et al. | Randomized | 2005 | n = 41 (Q7) n = 39 (AAP3) | - | AAP3 | Artesunate 4 mg/Kg/day, Atovaquone 20 mg/Kg/day, Proguanil 8 mg/Kg/day | 3 days |
| Rosa Mc Gready et al. | Randomized | 2000 | n = 65 (MAS3) n = 41 (Q7) | cure rate on day 42, confirmed by PCR | MAS3 | mefloquine 25 mg base/Kg (Total Dose) Artesunate 4 mg/Kg daily | 3 days |
| Rosa Mc Gready et al. | Randomized | 2001 (1997-2000) | n = 65 (QC7) n = 64 (A7) | cure rate on day 42, confirmed by PCR | None | Quinine (10 mg salt/Kg every 8 hours)/Clindamycin (5 mg/Kg every 8 hours) versus Artesunate 2 mg/Kg | 7 days versus 7 days |
| Pola et al. | Randomized | 2010 | n = 138 (AL) n = 125 (Q) | cure rate on day 42, confirmed by PCR with a non-inferiority margin, a difference in cure rate of 5% | None | - | - |