Characteristics

Wild-type RAS

Mutated RAS

P

Mean age

55.1

58.3

0.035

≤55

57 (42.9%)

58 (38.9%)

>55

76 (57.1%)

91 (61.1%)

Gender

Female

64 (48.1%)

84 (56.4%)

0.166

Male

69 (51.9%)

65 (43.6%)

Personal history

CRC

6 (4.5%)

9 (6%)

0.567

Other cancers

1 (0.8%)

3 (2%)

0.591

Family history

CRC

19 (14.3%)

14 (9.4%)

0.188

Other cancers

7 (5.3%)

14 (9.4%)

0.629

Tumor site

Right colon

28 (21.1%)

21 (14.1%)

0.147

Left colon

60 (45.1%)

80 (53.7%)

Rectum

45 (33.8)

48 (32.2%)

Histological subtype

Lieberkuhnian

123 (92.5%)

132 (88.6%)

0.137

Mucinous

7 (5.3%)

17 (11.4%)

Others

3 (2.2%)

0

Tumor grade

Well

29 (21.8%)

55 (36.9%)

0.003

Moderate

79 (59.4%)

83 (55.7%)

Poor

25 (18.8%)

11 (7.4%)

Mean tumor size

5.34

5.93

0.423

Vascular invasion

Yes

26 (19.5%)

28 (18.8%)

0.854

No

23 (17.3%)

23 (15.4%)

Not specified

84 (63.2%)

98 (65.8%)

Perineural invasion

Yes

19 (14.3%)

18 (12%)

0.382

No

18 (13.5%)

24 (16.1%)

Not specified

96 (72.2%)

107 (71.8%)

Diseases stages

I

1 (0.8%)

0

0.689

II

4 (3%)

4 (2.7%)

III

8 (6%)

7 (4.7%)

IV

87 (65.4%)

102 (68.4%)

Not specified

33 (24.8%)

36 (24.2%)

Lymph nodes invasion

N0

15 (11.3%)

16 (10.7%)

0.312

N+

27 (20.3%)

34 (22.8%)

Not specified

91 (68.4%)

99 (66.4%)

Distant metastases

Liver

57 (65.5%)

60 (58.8%)

0.421

Lung

32 (36.8%)

47 (46.1%)

0.151

Peritoneum

26 (29.9%)

33 (32.3%)

0.644

Bone

4 (4.6%)

8 (7.8%)

0.396

MSI

MMR

17 (12.8%)

31 (20.8%)

0.255

MSI

5 (3.6%)

4 (2.7%)

Not specified

111

114

BRAF

WT

52 (39.1%)

99 (66.4%)

0.037

Mutated

5 (3.8%)

0

Not specified

76 (57.1%)

50 (33.6%)

PI3K

WT

48 (36.1%)

77 (51.7%)

0.169

Mutated

8 (6%)

22 (14.8%)

Not specified

77(57.9%)

50 (33.5%)

Total

133

149