Gene alterations

Exon

Nucleotide substitution

Codon

Substitution

Number (n = 149)

Percentage (%)

KRAS

2

c.35G > A

G12D

47

31.5

2

c.35G > T

G12V

40

26.8

2

c.38G > A

G13D

20

19.5

2

c.34G > T

G12C

10

6.7

2

c.35G > C

G12 A

9

6.04

2

c.34G > A

G12S

3

2.01

2

c.37G > T

G13C

1

0.7

3

c.175G > A

p.A59T

1

0.7

3

c.182A > T

p.Q61L

1

0.7

4

c.436G > A

p.A146T

3

2.01

4

c.437C > T

p.A146V

1

0.7

4

c.351A > T

p.117A

2

1.3

NRAS

3

c.181C > A

p.Q61K

4

2.7

3

c.181A > G

p.Q61R

2

1.3

3

c.183A > C

p.Q61H

1

0.7

2

c.35G > A

p.G12D

2

1.3

3

c.182A > G

Glu61Arg

2

1.3