| Cytogenetic change | Risk category |
| Philadelphia chromosome | Poor prognosis |
| t (4; 11) (q21; q23) | Poor prognosis |
| t (8; 14) (q24.1; q32) | Poor prognosis |
| Complex karyotype (more than four abnormalities) | Poor prognosis |
| Low hypodiploidy or near triploidy | Poor prognosis |
| Deletion of chromosome 7 | Poor prognosis |
| Trisomy 8 | Poor prognosis |
| High hyperdiploidy (trisomy 4, 10, 17) | Good prognosis |
| del (9p) | Good prognosis |