| Factor | Unfavorable | Favorable |
| Age | <2 or >10 years | 3 - 5 years |
| Sex | Male | Female |
| Race | Black | Caucasian |
| Organomegaly | Present | Absent |
| Mediastinal mass | Present | Absent |
| CVS involvement | Present | Absent |
| Leukocyte count | B-ALL > 30,000 mm3 T-ALL > 100,000 mm3 | Low |
| Hemoglobin concentration | >10 g/dl | <10 g/dl |
| Cell type | Non Lymphoid | Lymphoid |
| Cell lineage | Pre B cell + T-ALL (children) | Early Pre B cell |
| Karyotype | Translocation | Hyperdiploidy |
| Response to treatment | Slow > 1 week to clear blasts from blood | Rapid < 1 week to clear blasts from blood |
| Time to remission | >4 weeks | <4 weeks |
| Minimal residual disease | Positive at 3 - 6 months | Negative at 1 month (children) or 3 months (adults |