| Virulence Type | Serogroup | Disease | Summary of Host Cell Interaction |
| Enteropathogenic (EPEC) | 055 H6, NM 086 H34, NM 0111 H2, H12, NM 0119 H6, NM 0125ac H21 0126 H27, NM 0128 H2, H12 0142 H6 | ‒ Enteritis in infants ‒ Traveler’s diarrhoea | ‒ EPEC attach to intestinal mucosal cells causing cell structure alterations (attaching and effacing) ‒ EPEC cells invade the mucosal cells |
| Enterotoxigenic (ETEC) | 06 H16 08 H9 011 H27 015 H11 020 NM 025 H42, NM 027 H7 078 H11, H12 0128 H7 0148 H28 0149 H10 0159 H20 0173 NM | ‒ Diarrhoea, vomiting and fever ‒ Traveler’s diarrhoea | ETEC adhere to the small intestinal mucosa and produce toxins that act on the mucosal cells |
| Verocytotoxigenic (VTEC; including enterohaemorrhagic, EHEC) | 026 H11, H32, NM 055 H7 0111ab H8, NM 0113 H21 0117 H14 0157 H7 | ‒ Shigella-like dysentery (stool contain blood and mucus) ‒ Haemolytic uraemic syndrome | EHEC attach to and efface mucosal cells and produce toxin |
| Enteroinvasive (EIEC) | 028ab NM 029 NM 0112ac NM 0124 H30, NM 0136 NM 0143 NM 0144 NM 0152 NM 0159 H2, NM 0164 NM 0167 H4, H5, NM | Shigella-like dysentery | EIEC invade cells in the colon and spread laterally, cell to cell |
| Enteroaggregative (EAEC) | 03 H2 015 H18 044 H18 086 NM 077 H18 0111 H21 0127 H2 | Persistent diarrhoea in children | EAEC bind in clumps (aggregates) to cells of the small intestine and produce toxins |
| Diffusely adherent (DAEC) | Not yet established | Childhood diarrhoea | Fimbrial and non-fimbrial adhesions identified |