| Properties | Sulfasalazine | Sulfafurazol | Sulfadimidine | Sulfadiazine | Sulfamethoxazole | Sulfacetamide |
| Blood-Brain Barrier | BBB+ | BBB+ | BBB+ | BBB+ | BBB+ | BBB+ |
| Human Intestinal Absorption | HIA+ | HIA+ | HIA+ | HIA+ | HIA+ | HIA+ |
| Caco-2 Permeability | Caco2− | Caco2− | Caco2+ | Caco2+ | Caco2− | Caco2− |
| P-glycoprotein Substrate | Non-substrate | Non-substrate | Non-substrate | Non-substrate | Non-Substrate | Non-Substrate |
| CYP450 2C9 Substrate | Non-substrate | Non-substrate | Non-substrate | Non-substrate | Non-substrate | Non-substrate |
| CYP450 2D6 Substrate | Non-substrate | Non-substrate | Non-substrate | Non-substrate | Non-substrate | Non-substrate |
| CYP450 3A4 Substrate | Non-substrate | Non-substrate | Non-substrate | Non-substrate | Non-substrate | Non-substrate |
| CYP450 1A2 Inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor |
| CYP450 2C9 Inhibitor | Inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor |
| CYP450 2C19 Inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor |
| CYP450 3A4 Inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor | Non-inhibitor |
| CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity |
| AMES Toxicity | Non AMES toxic | Non AMES toxic | Non AMES toxic | Non AMES toxic | Non AMES toxic | Non AMES toxic |
| Carcinogens | Non-Carcinogens | Non-Carcinogens | Non-Carcinogens | Non-Carcinogens | Non-Carcinogens | Non-Carcinogens |
| Biodegradation | Not ready biodegradable | Not ready biodegradable | Ready biodegradable | Ready biodegradable | Not ready biodegradable | Not ready biodegradable |
| Acute Oral Toxicity | III | IV | III | III | IV | III |
| Carcinogenicity (Three-class) | Non-required | Non-required | Non-required | Non-required | Non-required | Non-required |