Parameters

CBZ

CBZ-NRG cocrystal

CBZ-NRG physical mixture

C_max (ng/mL)

5258.1 ± 904.2

491.3 ± 97.6

737.3 ± 335.6

T_max (h)

0.7 ± 0.2

8.5 ± 1.0

2.1 ± 1.5

t_1/2 (h)

1.6 ± 0.1

7.2 ± 2.1

10.2 ± 6.1

AUC_0-∞(ng∙h/mL)

15,356.2 ± 1756.4

10,431.1 ± 2014.3

14,968.3 ± 8135.7