Kim et al. [55] , 2009 Korea

double-blind, placebo- controlled study (RCT)

143 patients with ED

1000 mg of tissue-cultured mountain ginseng extract (TGME) or 1000 mg of placebo twice a day for 8 weeks

Korean version of International Index of Erectile Function (IIEF) questionnaire

The scores of 5 domains of IIEF after medication were significantly higher than baseline scores in the group treated with TGME. No significant improvement was observed in the placebo group.

Hong et al. [27] , 2002 Korea

double-blind, placebo controlled, crossover study (RCT)

45 patients with ED

900 g of Korean red ginseng or placebo 3 times daily (8 weeks on treatment, 2 weeks of washout and 8 weeks on treatment)

・ International Index of Erectile Function (IIEF)

・ Rigiscan

・ Penile duplex ultrasonography

Mean IIEF scores were significantly higher in patients treated with Korean red ginseng than in those who received placebo. Among other variables, penile tip rigidity on Rigiscan showed significant improvement for ginseng versus placebo.