Features | Exosomes | Microvesicles | Apoptotic Bodies |
Diameter | 30 - 150 nm | 50 - 1000 nm | 1000 - 5000 nm |
Appearance | cup - shape | cup - round shapes | variable shapes |
Density in (Sucrose Gradient) | 1.13 - 1.19 g/mL | 1.04 - 1.07 g/mL | 1.16 - 1.28 g/mL |
Sedimentation | 100,000 g | 10,000 g | 16,000 g |
Marker Proteins | tetraspanins, Alix, TSG101 | integrins, selectins, CD40 ligand | histones |
Origin | Endosome budding into MVBs, fusion of MVB with cell membrane | Outward budding of cell membrane | Outward blebbing of apoptotic cell membrane |
Composition | Protein, lipids, coding RNA, Noncoding RNA, DNA | Protein, lipids, cell organelles, coding RNA, noncoding RNA, DNA | Cell organelles, proteins, nuclear fragments, coding RNA, noncoding RNA, DNA |