| HTLV-1 receptors | Cellular localization | Role in viral entry | Exception |
| GLUT-1 or carrier of glucose-1 | Ubiquitous in all laboratory lines Overexpressed after activation of cells or in cells in proliferation | Late entry events such as the merger | Glioblastoma/Astroglioma lines do not express GLUT-1 but are susceptible to HTLV-1 infection |
| BDCA-4 or NRP-1 or CD304 or VEGF165R | In vivo: activated T lymphocytes, dendritic cells (DC), endothelial cells and certain tumor cell lines In vitro: expression in almost all lines, particularly dendritic cells | Binding of the HTLV-1 (SU) env protein to the surface of the target cell, formation of syncytia | Possible infection in the presence of antibodies blocking the interaction between HTLV-1 and NRP-1 in dendritic cells |
| Heparin Sulphate Proteoglycans (HSPG and syndecan 1 and 2) | All cells. HSPGs are a component of the matrix extracellular | Attachment factors and virion concentration on the surface of the target cell Ensure the recruitment of NRP-1 | Unactivated CD4 + T cells express little or no HSPG. Possible infection in the presence of antibodies blocking the interaction between HSPG and HTLV-1 in dendritic cells |
| DC-SIGN | Dendritic cells, dendritic cells derived from monocytes (MDDC), myeloid dendritic cells and B cell lines | Attachment factor and virion concentration to the dendritic cell membrane. Also involved in virus transmission from dendritic cells to T lymphocytes | Expression restricted to a few subtypes of dendritic cells, but no expression in pDC |