| Biomarker | Squamous cell carcinoma | Adenocarcinoma | Small cell Lung cancer | Large cell neuroendocrine carcinoma |
| CEA | ↑ | ↑ | ↑ | ↑ |
| PSF3 | - | ↑↑ | - | - |
| Pro GRP | - | - | ↑↑ | - |
| SCCA | ↑↑ | - | - | - |
| NSE | - | - | ↑↑ | - |
| CYFRA 21-1 | ↑↑ | - |
| - |
| SST | - | - | - | ↑↑ |