Mechanochemical

General procedure

Solvent

none

DMSO (150 mL), Toluene (250 mL), isopropanol (150 mL), water (300 mL)

Starting materials

Z9 (0.258 g) and D7 (0.67 g)

Z9 (50 g) and D7 (20.87 g)

Nonrecycled solvent waste

0.2 mL Ethanol

55 mL organic solvent

Cat. or reagent

DBU (0.197 g)

Potassium carbonate (33.54 g)

Waste

Ethanol, DBU, PPh₃O

water, KBr, PPh₃O

R₁

0.4 g

45.0 g

E-factor (dimensionless)

~2.3

~9.2

Solvent recovery is calculated as 90%