| Technology | Clinical Trial Design | Investigator Year | Threshold | Number of Patients | Sensitivity | Specificity |
| Fluorescence Spectroscopy | ||||||
| Probe | ||||||
| Pilot | Ramanujam 1994 | SIL | 28 | 87 | 73 | |
| Pilot | Ramanujam 1996 | SIL | 64 | 91 | 76 | |
| Pilot | Ramanujam 1996 | SIL | 92 | 88 | 70 | |
| Pilot | Mitchell 1999 | SIL | 92 | 88 | 70 | |
| Pilot | Mitchell 1999 | SIL | 54 | 76 | 81 | |
| Pilot | Weingandt 2002 | HG | 68 | 88 | 53 | |
| Clinical Trial | Belinson 2001 | HG | 1997 | 94 | 9 | |
| Clinical Trial | Chang 2002 | HG | 146 | 71 | 70 | |
| Multispectral | ||||||
| Pilot | Wright 1999 | SIL | 19 | 99 | 95 | |
| Pilot | Dattamajurndar 2001 | SIL | 52 | 84 | 93 | |
| Pilot | Parker 2000 | HG | 35 | 80 | 81 | |
| Pilot | Parker 2002 | LG | 17 | 98 | 99 | |
| Reflectance Spectroscopy | ||||||
| Probe | ||||||
| Clinical Trial | Coppleson 1994 | HG | 163 | 90 | 90 | |
| Clinical Trial | Mirabal 2002 | HG | 161 | 72 | 83 | |
| Clinical Trial | Singer 2003 | HG | 651 | 70 | 77 | |
| Pilot | Mourant 2007 | HG | 36 | 100 | 80 | |
| Multispectral | ||||||
| Clinical Trial | Orfaoudaki 2005 | SIL | 134 | 91 | 100 | |
| Clinical Trial | Soutter 2009 | HG | 296 | 53 | 86 | |
| Clinical Trial | Louwers 2010 | HG | 239 | 65 | 70 | |
| Clinical Trial | Zaal 2012 | HG | 177 | 80 | 77 | |
| Pilot | Prabitha 2014 | HG | 41 | 100 | 100 | |
| Clinical Trial | Coronado 2016 | HG | 150 | 88 | 86 | |
| Clinical Trial | DeNardis 2017 | HG | 365 | 75 | 47 | |
| Combined Fluorescence and Reflectance Spectroscopy | ||||||
| Probe | ||||||
| Pilot | Geogeakoudi 2005 | SIL | 44 | 92 | 71 | |
| Clinical Trial | Chang 2005 | HG | 161 | 83 | 80 | |
| Clinical Trial | Cantor 2010 | HG | 1850 | 100 | 71 | |
| Clinical Trial | Yamal 2012 | HG | 1850 | 98 | 62 | |
| Clinical Trial | NCT01094132 2018 | HG | 552 | Pending | Pending | |