| Confirmation of Diagnosis | Treatment
| Confirmation of Recurrence | Confirmation of Response to PBT | Molecular Profiling | ||||||||||||
| Pathology | Radiology | |||||||||||||||
| Patient | Place and Date | Diagnosis | Place and Date | Diagnosis | Place and Date | Assessment | Place and Date | Assessment | OSD (Months) | OST (Months) | ||||||
| RECURRENT (PERSISTENT) AFTER CHEMOTHERAPY AND RADIATION THERAPY | ||||||||||||||||
| 1 | University hospital August 16, 2001 | Malignant mesothelioma right pleural effusion positive for malignancy | University hospital CT August 8, 2001 | Omental nodularities, ascites, pleural effusion | Exploratory laparoscopy, partial omentectomy, total abdominal hysterectomy and bilateral salpingo- oophorectomy August 10, 2001 |
|
|
|
| 157.3 + | 150.2 + |
| ||||
|
|
|
|
|
| Paclitaxel and carboplatin x3 August 21, 2001- October 3, 2001 | Regional radiology CT November 7, 2001 | Recurrence |
|
|
|
|
| ||||
|
|
|
|
|
| Topotecan to February 29, 2002 |
|
|
|
|
|
|
| ||||
|
|
|
|
|
| Thalidomide to March 12, 2002 | Regional radiology March 12, 2002 | Persistent disease |
|
|
|
|
| ||||
|
|
|
|
| Stage at admission to BC, Stage IV pleural and peritoneal malignant mesothelioma | BC. March 19, 2002. PB |
|
| Regional radiology PET December 6, 2002 and March 14, 2003 | CR |
|
|
| ||||
| 2 | University hospital May 4, 2005 | Malignant mesothelioma | Regional radiology CT April 18, 2005 | Mass within the left lower lobe, mediastinal lymph nodes, left pleural effusion | Decortication and pleurodesis May 5, 2005. RT × 3 days | Regional radiology CT September 21, 2005 | Recurrence |
|
| 13.8 | 9.0 |
| ||||
|
|
|
|
| Stage at admission to BC: Stage IV, Pleural malignant mesothelioma | BC. September 29, 2005 PB, erlotinib, imatinib, sorafenib, methotrexate. |
|
| Regional radiology CT November 25, 2005 | PD |
|
| VEGF and EGFR- elevated (blood) | ||||
| 3 | University hospital July 6, 2006 | Malignant mesothelioma | Regional medical center CT June 15, 2006 | Very large left pleural effusion. Large mass involving the left lateral aspects of the arch of aorta. | Pemetrexed July 18, 2006 | Regional radiology CT/PET August 1, 2006 | Persistent disease |
|
| 40.0 | 27.6 |
| ||||