ADE (incidence %)

REFERENCES

Middleton et al. 199824

Nowak et al. 200825

Vogelzang et al. 20033 Pemetrexed + Cisplatin 226

Vogelzang et al. 20033 Cisplatin

Burzynski et al. 2014

Grades

Grades

Grades

Grades

Grades

3

4

3

4

3/4

3/4

3

4

General

Fatigue

10.2

8.6

7.7

Fever

1.3

Infection

5.4

-

4

-

1.3

0.5

15.4

Hematologic

Hemoglobin

2.7

-

7

-

4.8

Leukopenia

10.8

2.7

30

6

17.7

0.9

7.7

Lymphopenia

Neutropenia

32

24

27.9

2.3

7.7

Thrombocytopenia

2.7

-

17

32

5.8

7.7

Gastrointestinal

Anorexia

2.2

0.5

7.7

Constipation

2.7

-

Diarrhea

-

-

2

-

4.4

15.4

Dyspepsia

Dehydration

4.0

0.5

Mucositis

-

-

7.7

Nausea/vomiting

8.1

-

20/17

-

14.6/13.3

6.3/3.6

−/7.7

Stomatitis

-

-

4

Cardiovascular

Hypertension

7.7

Chest pain

7.7

Neurologic

Paresthesia

7.7

Other

13

-

Dermatologic

Rash

1.3

Metabolic

Hypokalemia

7.7