Major manifestation

Minor manifestation

Carditis

Fever

Migratory polyarthritis

Arthralgia

Sydenham’s chorea

Elevated acute phase reactants (ESR, CRP)

Subcutaneous nodules

Prolonged PR interval on ECG

Erythema marginatum

Diagnosis is established if two major or one major + two minor plus

・ Supporting evidence of a recent group A streptococcal infection (positive throat culture or rapid antigen test, elevatedor increasing streptococcal antibody test)