Dose of epoetin at conversion

Low (<420 IU/kg/month)

(n = 30)

High (≥420 IU/kg/month)

(n = 31)

Total

(n = 61)

ESA dose (IU/kg/month), mean (SD)

Darbepoetin alfa

310.3 (79.0)

641.8 (178.5)

478.8 (216.5)

Epoetin beta pegol

At the time of switch

390.7 (111.9)

702.3 (245.3)

549.0 (246.6)

First month

380.0 (142.9)

650.8 (278.8)

517.6 (259.6)

Second month

366.1 (195.5)

649.3 (277.7)

510.0 (278.2)

Third month

338.7 (244.4)

638.4 (258.3)

491.0 (291.7)

ESA dose reduction (%), mean (SD)

At the time of switch

100.0

100.0

100.0

First month

99.5 (40.6)

90.7 (16.0)

95.0 (30.7)

Second month

95.5 (46.9)

90.8 (26.2)

93.1 (37.6)

Third month

86.3 (58.5)

90.7 (28.3)

88.5 (45.4)

ERI (IU/kg/month/g/dl), mean (SD)

Darbepoetin alfa

29.2 (7.6)

62.3 (19.1)

46.0 (22.1)

Epoetin beta pegol

At the time of a change

36.5 (11.0)

66.4 (25.0)

51.7 (24.4)

First month

35.6 (14.7)

61.2 (28.1)

48.6 (25.8)

Second month

34.5 (19.7)

61.7 (27.4)

48.3 (27.4)

Third month

32.3 (25.7)

60.0 (26.3)

46.4 (29.3)

ERI reduction (%), mean (SD)

At the time of a change

100.0

100.0

100.0

First month

99.7 (44.9)

89.9 (16.4)

94.7 (33.7)

Second month

96.2 (50.1)

91.1 (27.3)

93.6 (39.9)

Third month

87.2 (61.6)

90.3 (30.9)

88.7 (48.1)