1) Six or more café-au-lait macules (>0 - 5 cm at largest diameter in a prepubertal child or >1 - 5 cm in post-pubertal individuals)

2) Axillary freckling or freckling in inguinal regions

3) Two or more neurofibromas of any type or one or more plexiform neurfibromas

4) Two or more Lish nodules (iris harmatomas)

5) A distinctive osseous lesion (sphenoid wing dysplasia, lon-bone dysplasia)

6) An optic pathway glioma

7) A first degree relative with neurofibromatosis type 1 diagnosed by the above criteria