Variable | Hypofractionation arm | Conventional arm | |||||
Frequency | Percentage | Frequency | Percentage | ||||
1) Chemotherapy Neoadjuvant Adjuvant |
46 129 |
26.3 73.7 |
16 50 |
24.2 75.8 | |||
2) Chemotherapy schedule AC × 4 → Docetaxel × 4 AC × 4 → Paclitaxel × 4 TAC × 6 No chemotherapy |
87 38 35 - |
49.6 30.4 - 20 |
63 1 1 1 |
95 1.5 1.5 1.5 | |||
3) Radiation planning details (i) Supraclavicular fossa radiation field treatment (ii) Central lung distance Upto 1.5 cm 1.5 - 2.5 cm 2.5 - 3.5 cm >3.5 cm |
171
135 38 2 - |
97.7
77 - 22 1 |
66
50 15 1 - |
100
75.5 23 1.5 - | |||
4) Recurrence pattern Recurrence local recurrences [chest wall] systemic recurrences |
14 3 11 |
8 1.7 6.3 |
4 - 4 |
6 - 6 | |||
5) Systemic metastasis Brain Lung Liver Bone Contralateral breast |
4 4 2 1 - |
2.3 2.3 1.1 0.6 - |
- 2 1 - 1 |
- 3 1.5 - 1.5 | |||
6) Acute radiation reaction (i) Acute dermatitis grade 1 grade 2 grade 3 grade 4 |
18 9 4 2 |
10.3 5.1 2.2 1.1 |
19 7 7 1 |
28.8 10.6 10.6 1.5 | |||
(ii) Acute esophagitis grade 1 grade 2 grade 3 grade 4 |
15 15 1 - |
8.6 8.6 0.5 - |
6 1 - - |
9.1 1.5 - - | |||
(iii)Acute pneumonitis grade 1 grade 2 grade 3 grade 4 |
6 6 2 1 |
3.4 3.4 1.1 0.6 |
4 1 1 - |
6.1 1.5 1.5 - | |||