High specificity version

(98%/28%)c

Current commercial test

(91%/40%)c

Low specificity version

(80%/49%)c

Riska %

Frequencyb %

PPVd %

100-NPVe %

RRf

PPVd %

100-NPVe %

RRf

PPVd %

100-NPVe %

RRf

LOW

0 - 5

15

26.4

1.8

14.3

10.2

1.7

6.2

3.9

1.0

3.7

5 - 10

24

53.2

5.6

9.5

26.5

5.1

5.2

11.3

3.2

3.5

MID

10 - 15

8

66.7

9.5

7.0

38.8

8.6

4.5

18.3

5.5

3.3

15 - 20

7

74.8

13.5

5.5

48.5

12.3

4.0

25.0

8.0

3.1

20 - 25

6

80.3

17.6

4.6

56.3

16.1

3.5

31.3

10.6

3.0

25 - 30

4

84.2

21.8

3.9

62.8

20.0

3.1

37.3

13.4

2.8

30 - 35

3

87.1

26.1

3.3

68.2

24.1

2.8

43.0

16.4

2.6

35 - 40

3

89.4

30.6

2.9

72.7

28.3

2.6

48.5

19.7

2.5

40 - 45

3

91.2

35.2

2.6

76.7

32.8

2.3

53.7

23.2

2.3

45 - 50

3

92.7

39.9

2.3

80.1

37.4

2.1

58.7

27.0

2.2

50 - 55

3

93.9

44.8

2.1

83.1

42.2

2.0

63.4

31.1

2.0

55 - 60

3

95.0

49.8

1.9

85.7

47.1

1.8

68.0

35.6

1.9

60 - 65

2

95.9

55.0

1.7

88.1

52.4

1.7

72.3

40.5

1.8

HIGH

65 - 70

2

96.7

60.4

1.6

90.2

57.8

1.6

76.5

45.9

1.7

70 - 75

2

97.4

66.0

1.5

92.1

63.5

1.5

80.5

51.8

1.6

75 - 80

2

98.0

71.7

1.4

93.9

69.4

1.4

84.4

58.4

1.4

80 - 85

2

98.5

77.6

1.3

95.4

75.7

1.3

88.1

65.8

1.3

85 - 90

2

99.0

83.7

1.2

96.9

82.2

1.2

91.7

74.1

1.2

90 - 95

2

99.4

90.1

1.1

98.2

89.0

1.1

95.1

83.4

1.1

95 - 100

4

99.8

96.6

1.0

99.4

96.3

1.0

98.4

94.1

1.0

% Up

10.1

10.4

7.6

% Down

16.8

15.5

14.9