Regime | Details | Total dose* initial period & its length | Average dose* q day initial period | Total dose* complete Regime | Av. daily* dose Total Regime | Total length 3 infusions minimum | Total length 3 infusions maximum | Peak dose level |
Standard | 60 to 75*^ | 70* | 3.57 | 3 courses | 3.56 | 70 | ||
Regime* [11] | q 21 days | q/21 days | 210*@ |
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Hudis High Dose*^ [39] | 90q 14 days x3 | 270/q 42 days | 6.43 | 270 | 2.14 | 90 | ||
regime~ 42 patients | total course | initial 42 | total 125 |
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G-Csf before and after dox | 126 days | day period | day period |
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dox 8 mgm/M2/day infusion | 24 hour daily |
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until toxicity | infusion with |
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[low dose group 23 patients] | 250 mcmg. | 80 - 99 | 4.22 | 236 | 4.24 | 44.0 days | 51.0 days | 9.6 |
[mid dose group 10 patients] | Gm-Csf q day | 101 - 124 | 6.67 | 301 | 5.16 | 53.0 days | 61.0 days | 9.7 |
[high dose group 34 patients] | sub cut. | 125 - 188 | 7.66 | 357 | 5.95 | 56.0 days | 85.0 days | 9.7 |
entire group 67 patients | each group | 132.04 | 7.08 | 322 | 5.22 | 58.4 days | 66.1 days | 9.7 |