Regime

Details

Total dose*

initial period

& its length

Average dose*

q day initial

period

Total dose*

complete

Regime

Av. daily*

dose

Total Regime

Total length

3 infusions

minimum

Total length

3 infusions

maximum

Peak

dose

level

Standard

60 to 75*^

70*

3.57

3 courses

3.56

70

Regime* [11]

q 21 days

q/21 days

210*@

Hudis High Dose*^ [39]

90q 14 days x3

270/q 42 days

6.43

270

2.14

90

regime~ 42 patients

total course

initial 42

total 125

G-Csf before and after dox

126 days

day period

day period

dox 8 mgm/M2/day infusion

24 hour daily

until toxicity

infusion with

[low dose group 23 patients]

250 mcmg.

80 - 99

4.22

236

4.24

44.0 days

51.0 days

9.6

[mid dose group 10 patients]

Gm-Csf q day

101 - 124

6.67

301

5.16

53.0 days

61.0 days

9.7

[high dose group 34 patients]

sub cut.

125 - 188

7.66

357

5.95

56.0 days

85.0 days

9.7

entire group 67 patients

each group

132.04

7.08

322

5.22

58.4 days

66.1 days

9.7