Parameter

miR-22 expression

p value

High (n = 225)

Low (n = 46)

Age (yr)

57.6 ± 12.8

56.7 ± 11.2

0.17^†

Gender

Male (n = 184)

147

37

0.046^‡

Female (n = 87)

78

9

Smoking

Smokers (n = 195)

189

6

<0.001^‡

Non-smokers (n = 76)

36

40

Stage

I (n = 47)

36

11

0.023^‡

IIa (n = 66)

50

16

IIb (n = 132)

112

20

IIIa (n = 27)

27

0

Cell differentiation

Well (n = 26)

8

18

<0.01^‡

Moderate (n = 173)

146

27

Poor (n = 72)

71

1

Mitotic index (#/10 HPF)

3.9 ± 2.5

5.6 ± 3.2

<0.001^†

Lymphovascular invasion

Positive (n = 168)

163

5

<0.001^‡

Negative (n = 103)

62

41