Insulin type

Onset of action (h)

Peak of action (h)

Duration of action (h)

Rapid acting analogs (aspart, glulisine, lispro)

0.15 - 0.35

1 - 3

3 - 5

Regular/soluble (short acting)

0.5 - 1

2 - 4

5 - 8

Intermediate acting Semilente (pork)

1 - 2

4 - 10

8 - 16

NPH (Neutral Protamine Hagedorn insulin)

2 - 4

4 - 12

12 - 24

IZS (insulin zinc suspension) Lente type

3 - 4

6 - 15

18 - 24

Basal long-acting analogs:

Glargine

Detemir

2 - 4

1 - 2

None

6 - 12

24

20 - 24

Long - acting: Ultralente type

4 - 8

12 - 24

20 - 30