Baseline

Total (n = 125)

No treatment (n = 52)

Steroids only (n = 12)

Immunosuppressives^* only (n = 38)

Both^** (Steroids + Immunosuppressives)

(n = 23)

P

Disease duration, years (SD)

1.6 (0.7)

1.6 (0.7)

1.6 (0.8)

1.9 (0.7)

1.4 (0.6)

0.102

Age, years (SD)

52.3 (11.9)

53.4 (12.2)

56.0 (14.9)

51.2 (11.5)

50.0 (10.4)

0.429

Female (%)

99 (79.2)

41 (78.8)

9 (75.0)

32 (84.2)

17 (73.9)

0.777

Current smoker (%)

14 (11.5)

5 (9.8)

2 (16.7)

5 (13.5)

2 (9.1)

0.989

Post high school education (%)

64 (52.5)

30 (58.8)

4 (33.3)

17 (45.9)

13 (59.1)

0.307

PTGA overall health (SD)

(0 - 10 VAS)

4.3 (2.6)

3.3 (2.5)

6.1 (2.4)

4.5 (2.2)

5.1 (2.4)

0.001

MID PTGA achieved (%)

59 (54.1)

18 (40.0)

9 (75)

18 (56.3)

14 (66.7)

0.038

Pain (SD)

(0 - 10 VAS)

3.9 (2.8)

3.1 (2.5)

3.8 (3.1)

4.7 (2.8)

4.6 (3.1)

0.051

MID pain achieved (%)

44 (40.4)

17 (37.8)

3 (36.4)

13 (40.6)

10 (47.6)

0.883

MDGA overall health (SD)

(0 - 10 VAS)

4.3 (2.3)

3.5 (2.2)

5.3 (2.4)

4.4 (2.1)

5.2 (2.4)

0.007

MID MDGA achieved (%)

49 (39.5)

19 (36.5)

7 (58.3)

15 (39.5)

8 (36.4)

0.560

HAQ (SD)

(0 - 3)

1.05 (0.72)

0.83 (0.70)

1.21 (0.84)

1.21 (0.71)

1.22 (0.60)

0.040

MID HAQ achieved (%)

36 (32.7)

10 (21.3)

6 (54.5)

15 (48.4)

5 (23.8)

0.025

Skin score (SD) (0 - 51)

21.0 (10.6)

21.1

(10.3)

21.1 (10.4)

21.5 (11.0)

20.0 (11.3)

0.961

MID skin score achieved (%)

44 (36.1)

17 (33.3)

5 (41.7)

15 (39.5)

7 (33.3)

0.899

ESR in mm/hr

24.1 (23.0)

23.5 (26.1)

18.4 (9.2)

27.5 (23.7)

23.6 (19.7)

0.698

CRP in mg/L (SD)

10.1 (14.7)

6.4 (6.3)

13.0 (20.4)

9.4 (8.3)

19.0 (27.0)

0.013

TLC % predicted (SD)

91.0 (18.0)

91.0 (18.0)

94.1 (21.4)

91.5 (16.0)

89.0 (19.4)

0.921

FVC % predicted (SD)

87.4 (18.7)

87.4 (18.7)

95.3 (18.0)

88.6 (18.0)

79.6 (18.9)

0.092

DLCO % predicted (SD)

68.7 (19.7)

68.7 (19.7)

65.4 (19.2)

68.7 (20.5)

56.9 (19.4)

0.014