USA [30]

1980-2009

37

28 WLE

5 exenteration

5 EBRT, CT

Progression-free survival: 11.4 months,

Overall survival: 19 months.

USA [57]

1970-2009

15

WLE, EBRT, CT, IM

2/15 alive over 8 years follow-up

China [34]

1970-2005

31

15 Surgery & IM

7 surgery

4 CT & IM

3 CT

2 no treatment

35.5% recurrence; 32.3% 5 year survival

USA [35]

1976-1986

5

5 WLE

3 CT, IM

Time to recurrence 7 months; mean survival 31 months

USA [36]

1970-2002

26

7 exenteration

10 WLE

3 RH V; 1 V

3 EBRT only

Fifteen patients died of the disease (3 - 83 months)

Four patients no evidence of disease (5 - 24 months)

Four patients alive with disease (6 - 276 months)

USA [37]

1977-2001

35

10 WLE

2 V

10 RH V

2 exenteration

11 EBRT, 26 IM or CT

Median survival 20 months

Surgical therapy: median survival 25 months

Radiation therapy: median survival 13 months

United Kingdom [50]

1975-2000

9

2 EBRT

1 RH,V

6 WLE

Median survival 24 months (range 4 to 60 months)

China [16]

1979-1997

9

9 surgery, CT, IM

20% 5-year survival; one long term survivor at 19 years

USA [38]

1990

10

10 surgery, EBRT, CT

Mean time to recurrence: 8 months

Mean survival: 15 months

Austria [39]

1982-1996

14

7 biopsy

5 WLE

1 RH V

1 exenteration

Mean survival 10 months (range 1 - 153)

21% 5-year survival

USA [40]

1966-1996

7

2 WLE

2 WLE, EBRT

2 ICRT

1 exenteration

Median time to death 20 months (2 ot 48 months)

All Dead of disease

USA [41]

1982-1996

13

5 V

9 WLE

64% Estimated 5-year survival

USA [42]

1972-1992

8

4 conservative: WLE, CT, EBRT

4 Radical: exent, RH

4 patients radical surgery: 75% 2-year survival

4 patients conservative surgery: 0% 2-year survival

Italy [43]

1969-1993

20

15 WLE

15 evaluable patients; 2 died postoperatively

All patients died of disease; median survival 19 months

USA [44]

1986-1992

4

4 exenteration

All underwent pelvic exenteration;

One post operative death

Three patients alive at 31-to 97 months

Hong Kong [45]

1978-1990

10

1 exenteration, CT

2 RH V

3 WLE

3EBRT ± CT

Five patients died 2 - 22 months

Five patients median survival 18 months

USA [46]

1936-1988

15

3 WLE

2 RH V

5 V, vulvectomy

3 exenteration

2 EBRT

17.4% 5-year survival

Two patients survival more than 5 years

Spain [47]

1984, 1986

2

1 RH V

1 EBRT

Died at 4 and 6 months

Sweden [48]

1960-1984

26

Not stated

13% 5-year survival

USA [49]

1935-1976

19

7 RH V

8 WLE, EBRT

4 EBRT, ICRT

21% 5-year survival

One long-term survivor at 14 years