Aristolochia taliscana | Roots | Hexane | (−) Licarin A | M. tuberculosis H37Rv or MDR. TB murine model | Low toxicity together with the discrete bacteriostatic activity | [80] | |||
Hypericum species | Aerial parts | Ethanol | Identification needed | M. tuberculosis H37Rv (ATCC 27,294), H37Rv isoniazid-resistant (ATCC 35,822), H37Rv rifampin-resistant (ATCC 35,838), H37Rv ethambutol-resistant (ATCC 35,837), M. fortuitum, M. smegmatis (ATCC 35,798), M. avium (ATCC 35,717), M. chelonaeand four drug-resistant strains. Microplate Alamar Blue Assay (MABA) | Potent activity was observed from H. foliosum, H. hircinum subsp. majus, H. grandifolium, H. humifusum and H. elodeswith MICs ranging from 25 to 50 μg/mL. H. elodes and H. hircinum subsp. majus were also active against drug resistant clinical isolates with MICs ranging from 12.5 to 50 μg/mL | [81] | |||
Chamaedorea tepejilote | Aerial parts | Hexane | Ursolic and oleanolic acids | M. tuberculosis H37Rv (ATCC 27294), four mono-resistant strains of M. tuberculosis H37Rv. Modified Microplate Alamar Blue Assay (MABA) | Both the compounds showed MIC range from 12.5 μg/mL to 50 μg/mL | [82] | |||
Robinia hispida | |||||||||
Diospyros anisandra | Stem bark | n-hexane | Maritinone and 3,3’-biplumbagin | Two strains of MTB (H37Rv) susceptible and one MDR clinical isolates. Modified Microplate Alamar Blue Assay (MABA) | Plumbagin and its dimers maritinone and 3,3’-biplumbagin showed the strongest activity against both MTB strains (MIC = 1.56 - 3.33 μg/mL | [83] | |||
Ranunculi Ternati Radix | Whole plant | Water, 70% ethanol and water eluted part of ethanol extract | Identification needed | H37Rv (ATCC 95054), MDR-TB (2314-2) and XDR-TB strains, Vivo experiments were performed on C57BL/6 mice | 70% ethanol eluted part of EE from D101 macroporous resin showed stronger inhibitory effect on MDR2314-2 and XDR1220. MIC 1.0 mg/mL | [84] | |||
Chiness Herble Remidies (CHM) | CHM as an adjuvant to anti-TB chemotherapy may have beneficial effect for MDR-TB | [70] | |||||||
Andrographis paniculata | Herbs | Water, methylene chlolride, ethanol, nhexane and ethyl acetate | Identification needed | M. tuberculosis standard strain and MDR strain. Proportion methods using Lowenstein Jensen (L-J) medium | The proportion of inhibition of aqueous extract (2.5 mg/ml) of Rhoeo spathacea was 100% against M. tuberculosis H37Rv and MDR strain. | [85] | |||
Annona muricata | Dried leaves | ||||||||
Centella asiatica | Whole plant | ||||||||
Pluchea indica | Dried leaves | ||||||||
Rhoeospathacea | Dried leaves | ||||||||
Croton tonkinensis | Whole plants or leaves | --- | Diterpenoids including ent-kaurane, kaurane and grayanane | M. tuberculosis H37Ra (ATCC 27,294, H37rv (ATCC 35,835), MDR TB (KMRC 00116-00250), XDR TB (KMRC 00203-00197), (KMRC 00130-00064), (KMRC 00120-00137), (KMRC 00121-00341) and (KMRC 00122-00123, Resazurin Microtitre Assay (REMA) | All the di-terpenoids showed activity against susceptible and resistant strains. ent-1b,7a,14b-triacetoxykaur-16-en-15-one showed highest activity, MIC-3.125 - 6.25 µg/ml for MDR and XDR strains. | [86] | |||