Plant name (Botanical) | Family | Part Used | Solvent used for extraction | Chemical constituents | Anti-TB activity/MIC values | Reference |
Mallotus philippensis (Linn.) Muell Arg. | Euphorbiaceae | Leaves | First in 95% ethanol, than fractionation using t hexane, chloroform, ethyl acetate and metahnol | Ursolic acid and β-sitosterol | MIC for M. tuberculosis H37Rv and M. tuberculosis H37Ra is 0.25 and 0.125 mg/mL respectively in ethyl acetate fraction | [49] [50] |
Vetiveria zizanioides L. Nash | Poaceae | Roots | Hexane, ethyl acetate and methanol fractions from ethanolic extract | Need to be identify | MIC of the ethanolic extract of intact as well as spent root is 500 μg/mL whereas for the hexane fraction it is 50 μg/mL against M. tuberculosis H37Rv | [51] |
Withania somnifera (Linn.) | Solanaceae | Fresh leaves and roots | Water | Need to be identify | 1.0 mg/mL - 64.47% and 0.01 mg/mL - 17.88% inhibition of M. tuberculosis H37Rv | [52] |
Piper nigrum L. | Piperaceae | Seeds | Acetone, ethanol and distilled water | Piperine | MIC of acetone extract is 100 µg/mL and combination of acetone and ethanol extracts is 50 µg/mL against M. tuberculosis H37Rv | [53] |
Alstonia scholaris | Apocynaceae | Bark, flower, fruit and leaf | Ethyl acetate, butanol and water | Need to be identify | MIC of butanol extracts of flower and bark is of 500 and 100 µg/mL respectively against M. tuberculosis H37Rv | [54] |
Acacia catechu (L.) Willd | Mimosaceae | Roots | Sequentially extracted in water, ethanol, chloroform and hexane | Need to be identify | Most potent anti-mycobacterium activity shown by ethanol extracts of A. paniculata and A. catechu with MIC value 2.5 ± 1.45 mg/mL (5.0 mg/mL by [55] followed by chloroform extract of A. paniculata and ethanol extract of D. metel (05 ± 1.24 mg/mL) against M. tuberculosis H37Rv | [55] [56] |
Ailanthus excels Roxb. | Simaroubaceae | Roots | ||||
Aegle marmelos Corr. | Rutaceae | Leaf | ||||
Andrographis paniculata Nees. | Acanthaceae | Leaf | ||||
Datura metel L. | Solanaceae | Leaf | ||||
Vitex trifolia L. (syn. Vitex rotundifolia | Verbenaceae | Leaves | Cold methanol followed by fractionation in hexane, chloroform and n-butanol | Compound-1: 13-hydroxy-5(10), 14-halimadien-6-oneCompound-2: 6α,7α-diacetoxy-13-hydroxy-8(9),14-labdadieneCompound-3: 9-hydroxy-13(14)-labden-15, 16-olide) and Compound-4: Isoambreinolide | MIC for compound 3 and 4 is 100 and 25 μg/mL respectively against M. tuberculosis HRv (ATCC27294) | [57] |