Plant name (Botanical)

Family

Part Used

Solvent used for extraction

Chemical constituents

Anti-TB activity/MIC values

Reference

Mallotus philippensis (Linn.) Muell Arg.

Euphorbiaceae

Leaves

First in 95% ethanol, than fractionation using t

hexane, chloroform, ethyl acetate and metahnol

Ursolic acid and β-sitosterol

MIC for M. tuberculosis H37Rv and M. tuberculosis H37Ra is 0.25 and 0.125 mg/mL respectively in ethyl acetate fraction

[49] [50]

Vetiveria zizanioides L. Nash

Poaceae

Roots

Hexane, ethyl acetate and methanol fractions from ethanolic extract

Need to be identify

MIC of the ethanolic extract of intact as well as spent root is 500 μg/mL whereas for the hexane fraction it is 50 μg/mL against M. tuberculosis H37Rv

[51]

Withania somnifera (Linn.)

Solanaceae

Fresh leaves and roots

Water

Need to be identify

1.0 mg/mL - 64.47% and

0.01 mg/mL - 17.88% inhibition of M. tuberculosis H37Rv

[52]

Piper nigrum L.

Piperaceae

Seeds

Acetone, ethanol and distilled water

Piperine

MIC of acetone extract is 100 µg/mL and combination of acetone and ethanol extracts is 50 µg/mL against M. tuberculosis H37Rv

[53]

Alstonia scholaris

Apocynaceae

Bark, flower, fruit and leaf

Ethyl acetate, butanol and water

Need to be identify

MIC of butanol extracts of flower and bark is of 500 and 100 µg/mL respectively against M. tuberculosis H37Rv

[54]

Acacia catechu (L.) Willd

Mimosaceae

Roots

Sequentially extracted in water, ethanol, chloroform and hexane

Need to be identify

Most potent anti-mycobacterium activity shown by ethanol extracts of A. paniculata and A. catechu with MIC value 2.5 ± 1.45 mg/mL (5.0 mg/mL by [55] followed by chloroform extract of A. paniculata and ethanol extract of D. metel (05 ± 1.24 mg/mL) against M. tuberculosis H37Rv

[55] [56]

Ailanthus excels Roxb.

Simaroubaceae

Roots

Aegle marmelos Corr.

Rutaceae

Leaf

Andrographis paniculata Nees.

Acanthaceae

Leaf

Datura metel L.

Solanaceae

Leaf

Vitex trifolia L. (syn. Vitex rotundifolia

Verbenaceae

Leaves

Cold methanol followed by fractionation in hexane, chloroform and n-butanol

Compound-1: 13-hydroxy-5(10), 14-halimadien-6-one

Compound-2: 6α,7α-diacetoxy-13-hydroxy-8(9),14-labdadiene

Compound-3: 9-hydroxy-13(14)-labden-15, 16-olide) and Compound-4: Isoambreinolide

MIC for compound 3 and 4 is 100 and 25 μg/mL respectively against M. tuberculosis HRv (ATCC27294)

[57]