Treatment group | NT | D1 | D2 | ||||
N = 35 | Mean (SD) | Mean (SD) | Difference vs NT | p-value | Mean (SD) | Difference vs NT | p-value |
iAUCa(0-15) | 142.1 (105.1) | 71.8 (48.5) | −70.3 (110.5) | 0.001 | 80.6 (49.0) | −61.6 (109.8) | 0.002 |
iAUC(0-30) | 635.8 (403.5) | 357.2 (177.5) | −278.5 (337.7) | <0.001 | 432.9 (248.6) | −202.9 (300.1) | <0.001 |
iAUC(0-45) | 1407.4 (784.6) | 841.1 (397.4) | −566.2 (558.2) | <0.001 | 992.1 (519.7) | −415.2 (484.7) | <0.001 |
iAUC(0-60) | 2162 (1112) | 1350 (628.0) | −812.2 (750.9) | <0.001 | 1518 (727.5) | −644.2 (868.6) | <0.001 |
iAUC(0-90) | 3239 (1586) | 2136 (964.6) | −1103 (1079) | <0.001 | 2289 (1034) | −950.5 (1092) | <0.001 |
iAUC(0-120) | 3951 (1876) | 2619 (1210) | −1332 (1272) | <0.001 | 2815 (1274) | −1136 (1343) | <0.001 |
iAUC(0-180) | 4738 (2303) | 3037 (1495) | −1701 (1503) | <0.001 | 3368 (1655) | −1370 (1601) | <0.001 |
Maximal concentration | 69.3 (33.1) | 47.0 (23.0) | −22.3 (22.9) | <0.001 | 51.3 (26.3) | −18.0 (17.3) | <0.001 |