Brand Name

(Generic Name)

Atrial Fibrillation Dosing

Adverse

Reactions

Discontinuation for Surgery

Cost, 30 Day Supply (Redbook)

Pradaxa®

(dabigatran) [6]

CrCL > 30 ml/min:

150 mg twice daily

CrCl 15 - 30 mL/min:

75 mg twice daily

Gastritis-like symptoms and Bleeding

CrCl ≥ 50 ml/min: 1 - 2 days

CrCl < 50 ml/min: 3 - 5 days before invasive or surgical procedures. Longer time periods may be considered for patients who may require complete hemostasis (e.g. major surgery, spinal puncture)

$349.99

Xarelto®

(rivaroxaban) [7]

CrCl > 50 ml/min: 20 mg once daily with evening meal

CrCl 15 - 50 mL/min: 15 mg once daily with evening meal

Bleeding

24 hours prior to surgery

$343.62

Eliquis®

(apixaban) [5]

5 mg twice daily In patients with 2 of the following characteristics:

- age ≥ 80 years

- body weight ≤ 60 kg

- SCr ≥ 1.5 mg/dL

2.5 mg twice daily

Bleeding

At least 48 hours prior to elective surgery or invasive procedures with a moderate or high risk of unacceptable or clinically significant bleeding.

At least 24 hours prior to elective surgery or invasive procedures with a low risk of bleeding or non-critical location and easily controlled.

$349.99