Brand Name (Generic Name) | Atrial Fibrillation Dosing | Adverse Reactions | Discontinuation for Surgery | Cost, 30 Day Supply (Redbook) |
Pradaxa® (dabigatran) [6] | CrCL > 30 ml/min: 150 mg twice daily
CrCl 15 - 30 mL/min: 75 mg twice daily | Gastritis-like symptoms and Bleeding | CrCl ≥ 50 ml/min: 1 - 2 days CrCl < 50 ml/min: 3 - 5 days before invasive or surgical procedures. Longer time periods may be considered for patients who may require complete hemostasis (e.g. major surgery, spinal puncture) | $349.99 |
Xarelto® (rivaroxaban) [7] | CrCl > 50 ml/min: 20 mg once daily with evening meal CrCl 15 - 50 mL/min: 15 mg once daily with evening meal | Bleeding | 24 hours prior to surgery | $343.62 |
Eliquis® (apixaban) [5] | 5 mg twice daily In patients with 2 of the following characteristics: - age ≥ 80 years - body weight ≤ 60 kg - SCr ≥ 1.5 mg/dL
2.5 mg twice daily | Bleeding | At least 48 hours prior to elective surgery or invasive procedures with a moderate or high risk of unacceptable or clinically significant bleeding.
At least 24 hours prior to elective surgery or invasive procedures with a low risk of bleeding or non-critical location and easily controlled. | $349.99 |