R

[8]

[51]

[52]

ORYZ_ASPFU

alp1

Alkaline protease 1

Ÿ Allows assimilation of proteinaceous substrates.

Ÿ Significant virulence factor in invasive aspergillosis. Involved in immune : efficiently cleaves C3, C4, C5, and C1q, as well as IgG, which leads to down-regulation of complement activation at the hyphal surface

Ÿ The role of Alp in the virulence of A. fumigatus is described contradictory: an Alp deficient A. fumigatus caused drastically reduced mortality in mice compared to the wild-type isolate, but this is not confurmed in other reports

8

8

512

0.0001

3.69

S

[1]

B0YB44

mepB

metallopeptidase MepB

Transcript induced by exposure to human airway epithelial cells and by growth on BSA as a sole nitrogen source

4

4

183

0.0040

1.80