R | [8] [51] [52] | ORYZ_ASPFU | alp1 | Alkaline protease 1 | Allows assimilation of proteinaceous substrates. Significant virulence factor in invasive aspergillosis. Involved in immune : efficiently cleaves C3, C4, C5, and C1q, as well as IgG, which leads to down-regulation of complement activation at the hyphal surface The role of Alp in the virulence of A. fumigatus is described contradictory: an Alp deficient A. fumigatus caused drastically reduced mortality in mice compared to the wild-type isolate, but this is not confurmed in other reports | 8 | 8 | 512 | 0.0001 | 3.69 |
S | [1] | B0YB44 | mepB | metallopeptidase MepB | Transcript induced by exposure to human airway epithelial cells and by growth on BSA as a sole nitrogen source | 4 | 4 | 183 | 0.0040 | 1.80 |