Degradation stages

Condition

% Impurities calculated against 0.1% POS standard

Mass balance (%)

Hydroxytriazole

Tosylated

Deshydroxy

Benzylated

SMUI (%)

% Total impurities

As such

Initial

ND

ND

0.06

0.04

0.04

0.25

104.0

Acid

60˚C, 3 hrs

ND

ND

0.10

0.05

0.11

0.43

104.3

Base

60˚C, 3 hrs

ND

ND

0.07

0.04

0.04

0.25

103.5

Peroxide

60˚C, 3 hrs

ND

ND

0.02

0.01

48.70

70.14

100.8

Neutral

60˚C, 3 hrs

ND

ND

0.08

0.04

0.04

0.26

104.7

Thermal

80˚C, 24 hrs

ND

ND

0.08

0.04

0.05

0.32

104.0

Sun light

3 hrs

ND

ND

0.04

0.06

1.31

4.09

102.5