Degradation stages | Condition | % Impurities calculated against 0.1% POS standard | Mass balance (%) | |||||
Hydroxytriazole | Tosylated | Deshydroxy | Benzylated | SMUI (%) | % Total impurities | |||
As such | Initial | ND | ND | 0.06 | 0.04 | 0.04 | 0.25 | 104.0 |
Acid | 60˚C, 3 hrs | ND | ND | 0.10 | 0.05 | 0.11 | 0.43 | 104.3 |
Base | 60˚C, 3 hrs | ND | ND | 0.07 | 0.04 | 0.04 | 0.25 | 103.5 |
Peroxide | 60˚C, 3 hrs | ND | ND | 0.02 | 0.01 | 48.70 | 70.14 | 100.8 |
Neutral | 60˚C, 3 hrs | ND | ND | 0.08 | 0.04 | 0.04 | 0.26 | 104.7 |
Thermal | 80˚C, 24 hrs | ND | ND | 0.08 | 0.04 | 0.05 | 0.32 | 104.0 |
Sun light | 3 hrs | ND | ND | 0.04 | 0.06 | 1.31 | 4.09 | 102.5 |