Parameters

Phase 1

(Male)

n = 16

Phase 2

(Male)

n = 15

Phase 3

(Male)

n = 18

P value

F value

Remark

GLU (mmol/l)

3.91 ± 2.27^a

4.69 ± 1.59^b

5.02 ± 2.57^c

0.0209

4.206

S

UREA (mmol/l)

4.24 ± 0.35^a

4.88 ± 0.69^b

5.10 ± 0.83^b

0.0017

7.373

S

CRT (µmol/l)

176.8 ± 62.74

218.0 ± 88.33

220.5 ± 67.03

0.1701

1.841

NS

AST (U/L)

54.56 ± 27.19

50.67 ± 23.73

63.02 ± 26.04

0.3734

1.006

NS

ALT (U/L)

24.96 ± 8.84^a

31.87 ± 10.9^b

31.98 ± 15.59^b

<0.0001

13.20

S

ALP (U/L)

25.81 ± 17.13

28.53 ± 9.08

34.16 ± 12.41

0.1948

1.694

NS