Study and Year	N	Design	Population	FFR cutoff	Outcomes
DEFER 2001 [19]	325	RCT	Stable CAD and intermediate stenosis without evidence of ischemia	0.75	No benefit stenting a non-ischemic stenosis
FAME 2009 [20]	1005	RCT	Multivessel CAD	0.80	Routine measurement of FFR in patients with multivessel CAD who underwent PCI with DES had a reduction in MACE at 1 year
FAME 2 2012 [22]	888	RCT	Stable CAD and hemodynamically significant stenoses	0.80	FFR-guided PCI with DES plus OMT vs OMT alone attenuated the rate of urgent revascularization. In negative FFR, OMT alone resulted in excellent outcomes, notwithstanding the angiographic assessment of the stenoses.
FAMOUS-NSTEMI 2014 [26]	350	RCT	NSTEMI referred for invasive management	0.80	FFR-guided management was associated with lower rates of revascularization versus angiography-guided management. Spontaneous MACE was more common in the FFR group during the 12-month follow-up.
DANAMI-3- PRIMULTI 2015 [27]	627	RCT	STEMI and multivessel disease who had undergone primary PCI of an infarct-related coronary artery	0.80	FFR-guided staged revascularization during index admission reduced the risk of future events and the need for revascularization.
Compare-Acute 2017 [28]	885	RCT	STEMI and multivessel disease who had undergone primary PCI of an infarct-related coronary artery	0.80	FFR-guided complete revascularization of non-infarct-related arteries in the acute setting resulted in lower MACE, including the need for revascularization.
IRIS-FFR 2017 [25]	5846	Prospective registry	At least one coronary lesion	0.75	Lesions with FFR ≤ 0.75: risk of MACE was significantly lower in revascularized lesions than deferred lesions. Lesions with FFR ≥ 0.76: risk of MACE was not significantly different between deferred and revascularized lesions.
Mayo Registry 2013 [30]	7358	Retrospective registry	PCI candidates without STEMI or cardiogenic shock	<0.75: PCI 0.75 - 0.80: Operator discretion >0.8: OMT	FFR-guided treatment was associated with a positive long-term outcome with a decreased reduction in MACE events.
RIPCORD 2014 [31]	200	Prospective observational study	Stable angina	0.80	Routine measurement of FFR at diagnostic angiogram affects the patient management approach.