| WHO clinical criteria for defining SM | Proposal for Adaptation to Pregnancy SM definition of WHO [15] |
| Resistance to insulin by one of the following | Resistance to insulin by one of the following |
| Type 2 Diabetes | Type 2 Diabetes |
| Impaired fasting glucose | Impaired fasting glucose ≥ 105 mg/dL |
| Impaired Glucose Tolerance | - |
| Insulin resistance defined euglycemic hyperinsulinemic clamp using the | Insulin resistance defined using the euglycemic hyperinsulinemic clamp or other sensitivity measuring method insulin, adjusted for gestational age |
| More any two of the following | More any two of the following |
| Antihypertensive and/or high blood pressure (systolic or diastolic ≥ 140 ≥ 90 mm/Hg) | Antihypertensive and/or high blood pressure (systolic or diastolic ≥ 140 ≥ 90 mm/Hg ) |
| Plasma triglycerides ≥ 150 mg/dl | Triglicerídeos plasmáticos ≥ 2 DP para a idade gestacional |
| ˂HDL cholesterol 39 mg/dl (in women) | Cholesterol HDL ˂ 2 DP for gestational age |
| ˃BMI 30 kg/m2 and/or the waist/hip ˃ 0.85 (in women) | IMC pre-pregnancy ˃ 30 Kg/m2 and/or waist/hip ratio ˃ 0.85 |
| Urinary albumin excretion rate ≥ 20 g/min or albumin creatinine ratio ≥ 30 mg/g | - |