| Table Serotonin modulatory effect on GABA | ||||
| Serotonin/receptors | GABA/ receptors | Mechanism involved | Location in brain regions | References |
| 5HT | GABAB | 5-HT inhibitsGABAB mediated IPSCs acting both pre and post synaptically | CA3 pyramidal neurons | [17] |
| 5HT | GABAB | 5-HT and GABAB receptors increase and decrease Ttype Ca2+ | Interneurons from stratum lacunosum-moleculare | [18] |
| 5-HT3 | GABA | Stimulates GABA release | Basolateral amygdala (from interneurons) | [19] [20] |
| 5-HT2 and 5-HT4 | GABAA | Modulate post synaptically GABAA mediated effect | Pyramidal neurons from prefrontal cortex | [21] |
| 5-HT2 | GABAA | Promotes Phosphorylation of GABAA receptors by activating on protein kinase C (PKC) which reduces GABAA mediated Cl− currents. | Pyramidal neurons from prefrontal cortex | [21] |
| 5-HT4 | GABAA | Modulates GABAA mediated current depending on protein kinase A (PKA)activation level | Pyramidal neurons from prefrontal cortex | [21] |
| 5HT | GABA | GABA release, strengthen local GABAergic inhibition and modulate thalamic processing of sensory signals | Dendrites of thalamic interneurons | [22] |
| 5-HT2 | GABAA | Enhances GABAA induced Cl− current acting through a protein kinase dependent pathway | Spinal dorsal horn, | [23] - [25] |