/1000 person-years

(95% CI)

2011

2012

2013

2014

Severe RVGE

77.1 (57.6 - 99.5)

22.2 (12.9 - 33.9)^**

40.3 (27.4 - 55.7)^**

14.6 (7.3 - 24.4)^**

% reduction

-

71.2% (50.3 - 83.4%)

47.7% (18.4 - 66.5%)

81.1% (63.8 - 90.1%)

Severe AGE

92.0 (70.5 - 116.2)

40.5 (27.5 - 55.9)^**

53.3 (38.3 - 70.9)^**

17.2 (9.2 - 27.8)^**

% reduction

-

56.0% (32.3 - 71.4%)

42.1% (13.9 - 60.9%)

81.3% (66.0 - 89.7%)

AGE

588.8 (532.3 - 648.1)

463.4 (416.4 - 512.8)^**

517.8 (468.2 - 569.9)

427.7 (382.3 - 475.6)^**

% reduction

-

21.3% (9.2 - 31.8%)

12.1% (−1.1 - 23.5%)

27.4% (15.9 - 37.3%)