Compounds | In vitro Cytotoxicity IC50 (µg/ml) | |||||
X | R | HCT-116 | Hela | PC3 | MCF-7 | |
CA-4 |
|
| 10.5 ± 0.73 | 9.4 ± 0.61 | 20.2 ± 1.12 | 5.3 ± 0.42 |
4a | CH2 |
| 58.7 ± 3.65 | 61.9 ± 3.42 | 53.0 ± 2.98 | 55.4 ± 3.11 |
4b | N-CH3 |
| 27.6 ± 1.98 | 20.1 ± 1.60 | 26.2 ± 1.82 | 17.1 ± 1.64 |
5a |
|
| 40.8 ± 2.73 | 33.5 ± 2.06 | 41.6 ± 2.21 | 37.5 ± 2.30 |
5b |
| Ph | 8.6 ± 0.51 | 8.2 ± 0.73 | 12.7 ± 0.88 | 6.9 ± 0.51 |
5c |
| COCH3 | 83.8 ± 4.73 | >100 | >100 | 84.9 ± 3.99 |
6a |
| CH3 | 22.6 ± 1.87 | 14.9 ± 1.23 | 17.7 ± 1.41 | 14.0 ± 1.41 |
6b |
| C2H5 | 29.3 ± 2.11 | 38.9 ± 2.25 | 28.5 ± 1.69 | 20.4 ± 1.85 |
6c |
| C3H7 | 19.8 ± 1.50 | 16.0 ± 1.32 | 18.9 ± 1.39 | 13.8 ± 1.42 |
7 |
|
| 63.4 ± 3.98 | 72.6 ± 3.83 | 74.5 ± 3.85 | 62.3 ± 3.35 |
8 |
|
| 52.6 ± 3.32 | 80.4 ± 4.05 | 65.8 ± 3.37 | 51.1 ± 2.89 |
9 |
|
| 70.6 ± 4.52 | 94.1 ± 4.53 | 97.3 ± 4.60 | 80.1 ± 3.74 |
10a | CH2 |
| 35.3 ± 2.24 | 50.5 ± 2.89 | 46.7 ± 2.38 | 31.8 ± 2.15 |
10b | N-CH3 |
| 92.9 ± 4.95 | >100 | 93.1 ± 4.12 | 89.5 ± 4.32 |
11a | CH2 |
| 96.4 ± 5.24 | 86.0 ± 4.19 | 82.9 ± 3.93 | >100 |
11b | N-CH3 |
| 65.4 ± 4.21 | 69.4 ± 3.60 | 50.9 ± 2.72 | 77.8 ± 3.58 |
12a |
| H | 34.1 ± 2.36 | 46.1 ± 2.61 | 36.0 ± 1.94 | 27.1 ± 1.97 |
12b |
| CH3 | 45.2 ± 2.92 | 25.9 ± 1.87 | 20.0 ± 1.47 | 39.9 ± 2.52 |
13 |
|
| 14.4 ± 1.05 | 11.4 ± 0.98 | 15.6 ± 1.20 | 9.1 ± 1.10 |
14 |
|
| 47.1 ± 3.14 | 57.1 ± 3.18 | 71.3 ± 3.65 | 45.6 ± 2.64 |
15 |
|
| 10.8 ± 0.92 | 9.5 ± 0.84 | 13.7 ± 0.97 | 8.8 ± 0.93 |
16 |
|
| 9.0 ± 0.68 | 7.8 ± 0.42 | 12.2 ± 0.81 | 7.9 ± 0.68 |
17 |
|
| 17.4 ± 1.32 | 13.1 ± 1.10 | 16.3 ± 1.36 | 10.7 ± 1.23 |